University Hospital Erlangen, Dept. of Neurology

University Hospital Erlangen

University Hospital Erlangen, Dept. of Neurology
Schwabachanlage 6
91054 Erlangen
Germany
http://www.neurologie.uk-erlangen.de/

Lead Investigator

Prof. Dr. med. Dr. h.c. Stefan Schwab

Prof. Dr. med. Dr. h.c. Stefan Schwab
Professor and Chairman
+49 9131-8534563
+49 9131-8536597
Contact

Project Staff

PD Dr. med. Dimitre Staykov

PD Dr. med. Dimitre Staykov
Neurologist
+49 9131 8533001
Contact

Institute Presentation

The Department of Neurology of the University Hospital Erlangen is part of the Friedrich-Alexander University Erlangen-Nürnberg. The Neurology Department houses one of the largest Stroke Units in Germany (14 beds), and one of the most important Neurointensive Care Units (NICU) worldwide. In 2009, over 1200 acute stroke patients were admitted to our hospital. 156 patients were treated by intravenous thrombolysis (rt-PA). In addition, patients are treated by intraarterial recanalisation strategies and decompressive surgery if indicated. Since 2006, we treated more than 100 patients with therapeutic hypothermia (TH) and prophylactic normothermia (by endovascular means). We performed different investigator initiated trials including COAST-I (ice-sold saline for induction of hypothermia in awake stroke patients) and COAST-II (mono centre phase-II study on endovascular cooling in awake stroke patients). After a pilot study in patients with large intracerebral hemorrhage treated by TH, we are currently conducting a German-Austrian multi centre trial (CINCH, registered trial-#: ) on this topic. 9 stroke centres are participating in this trial. In addition, Erlangen is the lead centre for the so called Depth-SOS study in which we are investigating in a multi- centre, randomized trial the combination effects of TH in patients with malignant MCA-Stroke treated by decompressive surgery. Prof. Schwab as the chair of the department was one of the first using therapeutic hypothermia in the treatment of stroke patients. Initially, in the mid-1990s, he used surface cooling. From the early 2000s we focused on endovascular cooling with temperaturefeed back. His co-worker, Rainer Kollmar, who is currently vice-chair o the department conducted several clinical investigations in TH. In addition, our neuroexperimental stroke group conducts animal studies in TH which answer questions for translational research. Our department is considered as the referral centre for hypothermia in stroke in Germany. We have experience in all kinds of cooling including local, endovascular, and surface cooling.

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